pp. 201-207
S&M1170 Research Paper of Special Issue https://doi.org/10.18494/SAM.2016.1281 Published: March 30, 2016 Development of Portable Quartz Crystal Microbalance for Biosensor Applications [PDF] Jinxing Liang, Jing Zhang, Peng Wang, Changchuan Liu, Shi Qiu, and Toshitsugu Ueda (Received November 18, 2015; Accepted February 29, 2016) Keywords: quartz crystal microbalance, flow injection analysis, high frequency, biosensor
In this work, we report a novel flow-injection-type portable quartz crystal microbalance (QCM) sensor utilizing a high-frequency (higher than 40 MHz) miniaturized QCM chip. The resonator chip is assembled in a novel three-layer flow cell, in which the top and bottom layers are used to fix the spring-pin leading electrodes and the middle layer is used to house the resonator chip. A two-stage operational transconductance-amplifier-(OPA660)-based oscillator circuit is developed to drive the QCM and measure the frequency shift. A low human IgG concentration of 1 ppm has been measured even using the simple physical adsorption antibody immobilization method, which indicates that the developed portable QCM sensor can be used as a biosensor in liquids.
Corresponding author: Jinxing LiangCite this article Jinxing Liang, Jing Zhang, Peng Wang, Changchuan Liu, Shi Qiu, and Toshitsugu Ueda, Development of Portable Quartz Crystal Microbalance for Biosensor Applications, Sens. Mater., Vol. 28, No. 3, 2016, p. 201-207. |