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Notice of retraction
Vol. 34, No. 8(3), S&M3042

Notice of retraction
Vol. 32, No. 8(2), S&M2292

Print: ISSN 0914-4935
Online: ISSN 2435-0869
Sensors and Materials
is an international peer-reviewed open access journal to provide a forum for researchers working in multidisciplinary fields of sensing technology.
Sensors and Materials
is covered by Science Citation Index Expanded (Clarivate Analytics), Scopus (Elsevier), and other databases.

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Sensors and Materials, Volume 30, Number 6(2) (2018)
Copyright(C) MYU K.K.
pp. 1333-1340
S&M1588 Research Paper of Special Issue
https://doi.org/10.18494/SAM.2018.1781
Published: June 29, 2018

Analysis of Process Parameters and Performance Test for Fabricating Stainless-steel Metal Microneedles [PDF]

Xiao-Xiao Yan, Gang Tang, Rui Hu, Bin Yang, Li-Ling Zhang, and Bin Xu

(Received October 20, 2017; Accepted January 4, 2018)

Keywords: metal microneedles, drug delivery, dicing, electrochemical corrosion

Using microneedles to transport drugs is one of the new, painless, and high efficient transdermal drug delivery methods, which has made great strides in recent years. However, many hollow and solid microneedles are usually made of silicon and polymer materials which have poor mechanical property. To improve their strength and reliability, in this study, metal microneedles were fabricated by dicing and electrochemical corrosion. Firstly, the process parameters of electrochemical corrosion, including current and solution, were discussed and analyzed in detail for fabricating microneedles with sharp tips. Secondly, the performance test of microneedles was carried out. In a force test, these microneedles could penetrate the artificial skin and the rat skin, and the skins were still well. In an in vitro transdermal drug delivery test, the amount of permeated flux of bovine serum albumin through treated rat skin increased by 5 times of the intact ones.

Corresponding author: Xiao-Xiao Yan


Cite this article
Xiao-Xiao Yan, Gang Tang, Rui Hu, Bin Yang, Li-Ling Zhang, and Bin Xu, Analysis of Process Parameters and Performance Test for Fabricating Stainless-steel Metal Microneedles, Sens. Mater., Vol. 30, No. 6, 2018, p. 1333-1340.



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