A low-noise analog front-end (AFE) with chopper-stabilized multipath current-feedback instrumentation amplifier (CFIA) for resistive sensors is proposed. Low-noise techniques are essential for the operation of precise resistive sensors, and chopper stabilization techniques have been commonly implemented in previous studies. However, techniques that are only based on chopper stabilization suffer from the disadvantage of a low bandwidth. To address this problem, a multipath operational amplifier is implemented in this work. Also, the chopper stabilization technique is implemented in the low-frequency path of a multipath operational amplifier. This chopper stabilization technique causes the “ripple” generated by the offset voltage. A ripple rejection loop in the low-frequency path is utilized to remove this ripple. In addition, a successive approximation register (SAR) analog-to-digital converter (ADC) is used to convert the measured analog signal into a digital output. The converter has an effective number of bits (ENOBs) of 11.02 and a signal-to-noise and distortion ratio (SNDR) of 75.68 dB. The resistive AFE with SAR ADC is designed using a 0.18 μm complementary metal-oxide-semiconductor (CMOS) process with an active area of 8.6 mm2. It operates at 2.56 mW with a 1.8 V supply and has an input-referred noise of 0.29 μVrms in the range of 1 to 100 Hz.