Good plant growth is ensured by suitable light source, temperature, humidity, carbon dioxide content, moisture, and nutrient conditions. In this paper, a plant cultivation driver system that consists of artificial light sources, ultrasonic nebulizers, and ventilation fans is proposed. By using the control scheme of pulse-width modulation, the output powers of the artificial light sources, the ultrasonic nebulizers, and the fans are adjusted. The artificial light sources use red, green, and blue light-emitting diodes (LEDs) to provide photosynthetic energy to plants. The ultrasonic nebulizers used for humidity control are installed near the plants to provide fine water molecules needed for plant leaves, and the fans provide them the desired temperature and venting environment. The driver uses the Arduino chip connected to the light, temperature, and humidity sensors to monitor these environmental parameters. Based on the environmental conditions fed back from the sensors, the chip can provide suitable growth conditions for plants by respectively controlling the light sources, atomizers, and fans. A 500 W prototype driver with update environmental parameters was designed and built. The output power range was adjusted from 60 to 460 W to meet plant growth requirements. The measured input power factor was higher than 0.92, and the highest conversion efficiency of the driver was 82.5%.