Cultural resources and the tourism industry are two major systems that are mutually inductive and restrictive. It is of great significance to correctly understand the sensitive relationship between them and make full use of a smart tourism data platform to build a coupling coordination sensing model of cultural tourism. In this paper, an evaluation index system for cultural resources and the tourism industry is constructed by taking 13 cities of Jiangsu in China as the study area, and the sensitivity between the two major systems is evaluated by using a combination of the information entropy weight (IEW) method and a coupling coordination degree model (CCDM). Using data on culture resources and the tourism industry in Jiangsu from 2009 to 2019, we analyzed the comprehensive development level as well as the coupling coordination characteristics of the two major systems from the perspective of spatiotemporal heterogeneity through big data analysis with the help of the Geographic Information System (GIS). It was concluded that the comprehensive development level of the two major systems has increased over time. The ecological culture and development support subsystems had the greatest contribution to the culture–tourism coupling system. The annual average coordination degree of each city has developed steadily to a high level while exhibiting a significant spatial dependence and a spillover effect. The sensing model in this study can be an important reference for culture and tourism development.