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Vol. 32, No. 8(2), S&M2292

Print: ISSN 0914-4935
Online: ISSN 2435-0869
Sensors and Materials
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Sensors and Materials, Volume 34, Number 3(1) (2022)
Copyright(C) MYU K.K.
pp. 987-1005
S&M2868 Review Paper of Special Issue
https://doi.org/10.18494/SAM3673
Published in advance: January 20, 2022
Published: March 3, 2022

In Vivo Topical and Systemic Distribution Kinetics of Liposomes with Various Properties for Application to Drug Delivery Systems [PDF]

Hisako Ibaraki and Takanori Kanazawa

(Received October 1, 2021; Accepted December 20, 2021)

Keywords: liposome, drug delivery system, biodistribution, skin application, systemic administration

Liposomes and lipid nanoparticles have been actively researched and developed as drug delivery carriers owing to their many advantages, such as high biocompatibility and degradability. Their in vivo kinetics depend on the route of administration, i.e., topical or intravenous, and their physical properties, such as particle size and surface charge. Designing liposomes that regulate in vivo kinetics and ensure efficient delivery to disease sites will result in excellent therapeutic effects. However, only a handful of studies have examined whether the characteristics and constituent lipids of liposomes can control histological and in vivo kinetics. In this review, we focus on the surface charge and polyethylene glycol (PEG) modifications of liposomes and evaluate their biodistribution. On the basis of our findings, we expound the effects of the intradermal permeability, inflammatory site accumulation, and physical properties of liposomes on systemic distribution kinetics.

Corresponding author: Takanori Kanazawa


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Cite this article
Hisako Ibaraki and Takanori Kanazawa, In Vivo Topical and Systemic Distribution Kinetics of Liposomes with Various Properties for Application to Drug Delivery Systems, Sens. Mater., Vol. 34, No. 3, 2022, p. 987-1005.



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