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Vol. 34, No. 8(3), S&M3042

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Vol. 32, No. 8(2), S&M2292

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Sensors and Materials, Volume 36, Number 6(1) (2024)
Copyright(C) MYU K.K.
pp. 2225-2235
S&M3664 Research Paper
Published: June 4, 2024

Point-of-Care Immunosensor for Epstein–Barr Virus Infection Detection Using a Biocarbon-based Platform [PDF]

Chen Chen and Meiling Liu

(Received March 4, 2024; Accepted May 27, 2024)

Keywords: flavivirus, neuroinflammation, electrochemical impedance, nanomaterials, infection control

We present the development of a novel point-of-care electrochemical immunosensor for the detection of the Epstein–Barr virus capsid antigen (EBVCA-IgA) using a biocarbon-modified screen-printed electrode platform. The biosensor achieves sensitive and rapid detection within a broad linear range of 0.1 pM to 10 nM of EBVCA-IgA, with an impressive limit of detection of 33 fM. The key to its practical utility is that the sensor operates efficiently, providing results in under one hour, which is a significant improvement over traditional methods such as enzyme-linked immunosorbent assays and polymerase chain reaction that typically exceed two hours. We also emphasize the sensor’s high selectivity by demonstrating minimal cross-reactivity with other common respiratory viruses. With its combination of rapidity, sensitivity, and simplicity, this biosensor represents a significant advancement in Epstein–Barr virus (EBA) diagnostics, which makes it particularly beneficial in clinical and low-resource settings where rapid and reliable testing is paramount.

Corresponding author: Meiling Liu

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Cite this article
Chen Chen and Meiling Liu, Point-of-Care Immunosensor for Epstein–Barr Virus Infection Detection Using a Biocarbon-based Platform, Sens. Mater., Vol. 36, No. 6, 2024, p. 2225-2235.

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