In this paper, geographic analysis methods in geographic information systems were applied to study and practice the ecological suitability influencing factors of traditional Chinese medicine resources. On the basis of the theory and methods of traditional Chinese medicine resource ecology, statistical ecology, and geographic analysis, the meaning and content of the ecological suitability of Chinese medicine resources were generally described. The indicator system of the ecological suitability of Chinese medicine resources was established. The analytic hierarchy process (AHP) was adopted to quantitatively and reasonably evaluate the impact of relevant indicators in the indicator system. The solution for the analysis and evaluation of suitability, which combines the AHP-Fuzzy method with geographic analysis methods, was proposed, and the geographic suitability analysis and ecological suitability evaluation models were established. The traditional Chinese medicine geographic suitability analysis system was designed and implemented on the basis of the Browser/Server framework to display the results of evaluation and analysis by 3D visualization. Experiments showed that the analysis results and the actual medicine’s plant growth are basically consistent, and the method for creating an indicator system and geographic analysis model was proved to be feasible and reasonable from a practical viewpoint.