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Print: ISSN 0914-4935
Online: ISSN 2435-0869
Sensors and Materials
is an international peer-reviewed open access journal to provide a forum for researchers working in multidisciplinary fields of sensing technology.
Online: ISSN 2435-0869
Sensors and Materials
is an international peer-reviewed open access journal to provide a forum for researchers working in multidisciplinary fields of sensing technology.
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Sensors and Materials
is covered by Science Citation Index Expanded (Clarivate Analytics), Scopus (Elsevier), and other databases.
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Sensors and Materials
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is covered by Science Citation Index Expanded (Clarivate Analytics), Scopus (Elsevier), and other databases.
Instructions to authors
English 日本語
Instructions for manuscript preparation
English 日本語
Template
English
Publisher
MYU K.K.
Sensors and Materials
1-23-3-303 Sendagi,
Bunkyo-ku, Tokyo 113-0022, Japan
Tel: 81-3-3827-8549
Fax: 81-3-3827-8547
MYU Research, a scientific publisher, seeks a native English-speaking proofreader with a scientific background. B.Sc. or higher degree is desirable. In-office position; work hours negotiable. Call 03-3827-8549 for further information.
MYU Research
(proofreading and recording)
MYU K.K.
(translation service)
The Art of Writing Scientific Papers
(How to write scientific papers)
(Japanese Only)
Sensors and Materials, Volume 20, Number 6 (2008)
Copyright(C) MYU K.K.
Copyright(C) MYU K.K.
|
pp. 281-288
S&M725 Research Paper of Special Issue https://doi.org/10.18494/SAM.2008.545 Published: December 4, 2008 Parallel and Passive Distribution to Arrayed Microwells Using Self-Regulating Pinched Flow [PDF] Kentaro Kawai, Masaki Kanai, Tatsuya Munaka, Hirohisa Abe, Akira Murakami and Shuichi Shoji (Received June 27, 2008; Accepted September 12, 2008) Keywords: passive distribution, parallel distribution, microwell array, self-regulating pinched flow, high throughput screening, cellular diagnostics
A parallel and passive (without any actuators or electrodes) cell distribution method for a cellular diagnostic microwell array was developed. This method can be used to simultaneously distribute cells evenly to arrayed microwells only by introducing cell suspensions into the inlet. To regulate the dispersion of the number of distributed cells into each microwell, we conceived a novel concept, the self-regulating pinched flow. The self-regulating pinched flow is realized in a functional microchannel, which consists of center micropillar colonnades and side channels. Computational fluid dynamics (CFD) simulations were carried out to optimize the design of the pinching area. We developed a prototype device that can be used to successfully distribute the beads uniformly in eight parallel microwells. The coefficient of variation (CV) of the distributed beads in the microwells was 29.3%.
Corresponding author: Kentaro Kawai Cite this article Kentaro Kawai, Masaki Kanai, Tatsuya Munaka, Hirohisa Abe, Akira Murakami and Shuichi Shoji, Parallel and Passive Distribution to Arrayed Microwells Using Self-Regulating Pinched Flow, Sens. Mater., Vol. 20, No. 6, 2008, p. 281-288. |
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