pp. 369-379
S&M853 Research Paper of Special Issue https://doi.org/10.18494/SAM.2011.744 Published: October 20, 2011 Implantable Distributed Biomedical Photonic Devices [PDF] Jun Ohta, Ayato Tagawa, Takuma Kobayashi, Toshihiko Noda, Kiyotaka Sasagawa and Takashi Tokuda (Received January 13, 2011; Accepted February 17, 2011) Keywords: biomedical photonic devices, complementary metal-oxide-semiconductor (CMOS) image sensor, implantable device, distributed implantation, brain imaging
In this paper, we demonstrate an implantable distributed biomedical photonic device that is based on a dedicated complementary metal-oxide-semiconductor (CMOS) image sensor architecture to measure fluorescence by implantation into the deep brain of an untethered mouse. To reduce tissue damage during implantation, an ultrasmall chip is fabricated using a standard 0.35 µm CMOS technology. The chip has an area of 547×700 µm2 and 60×60 pixels and is demonstrated to capture images. An implantable device is fabricated using three microchips, and the fundamental operation of the device is validated. The device successfully detected fluorescence from fluorescent beads excited externally. In addition, the device achieved simultaneous operation of the three microchips with a delay of less than 15 µs.
Corresponding author: Jun OhtaCite this article Jun Ohta, Ayato Tagawa, Takuma Kobayashi, Toshihiko Noda, Kiyotaka Sasagawa and Takashi Tokuda, Implantable Distributed Biomedical Photonic Devices, Sens. Mater., Vol. 23, No. 7, 2011, p. 369-379. |