pp. 667-671
S&M960 Research Paper of Special Issue https://doi.org/10.18494/SAM.2013.918 Published: December 16, 2013 Optimization of Microfluidic Immunomagnetic Chip for Circulating Tumor Cell Capture [PDF] Xiang Chen, Jinquan Liu, Jun Zhu, Yunfan Sun and Jia Fan (Received June 10, 2013; Accepted September 9, 2013) Keywords: immunomagnetic, CTC, microfluidic
The enumeration of circulating tumor cells (CTCs) has proved valuable for early detection and prognosis in cancer treatment. In this work, an optimized design of a microfluid-based immunomagnetic chip is proposed to separate CTCs from whole blood. Unlike most reported immunomagnetic-based methods in which the magnetic field is applied perpendicular to the flow direction, here, the magnetic field is applied parallel to the flow direction, which makes the hydrodynamic force not the dominant force to hamper cell capture. Experimental validation showed that this novel chip can be operated at a flow rate of up to 6 ml/h with 90% CTC capture efficiency.
Corresponding author: Xiang ChenCite this article Xiang Chen, Jinquan Liu, Jun Zhu, Yunfan Sun and Jia Fan, Optimization of Microfluidic Immunomagnetic Chip for Circulating Tumor Cell Capture, Sens. Mater., Vol. 25, No. 9, 2013, p. 667-671. |