The expectations of point-of-care technologies (POCT) are being increasingly shaped by thepatient-centric narrative of P5 (predictive, preventive, personalized, participatory, and populationbased)medicine. Shifting the focus of our healthcare system to a personalized and preemptiveapproach will depend partly on the availability of field-deployable measurement technologies thatprovide rapid biometric information to providers and patients. In order to respond to the changinghealthcare paradigm and hasten the integration of emerging sensor materials into clinically usefulpoint-of-care (POC) approaches, it is essential that the sensor materials community understandand appreciate the clinical context, expectations, and aspirations of the healthcare consumers.After reviewing the drivers of the P5 medicine initiative, we review the context within which thePOCT will be used, and some of the challenges associated with delivering portable, fast response,and highly reliable measurement technologies that can be used with complex biofluids in arange of settings by a variety of users. We conclude by emphasizing the potential synergies oflinking POCT’s to the “connected health” model which integrates mobile technologies, low-costhardware, healthcare IT systems, big data analytics, and the Internet of Things (IoT) to connectall stakeholders for a timely sharing of pertinent health information necessary for timely andpersonalized healthcare.