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Vol. 32, No. 8(2), S&M2292

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Sensors and Materials
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Sensors and Materials, Volume 28, Number 12 (2016)
Copyright(C) MYU K.K.
pp. 1317-1327
S&M1293 Research Paper of Special Issue
https://doi.org/10.18494/SAM.2016.1401
Published: December 14, 2016

Miniature Imaging Device with a Portable Processing System for Fluorescence Detection of Nitric Oxide in Living [PDF]

Anek Wuthayavanich, Makito Haruta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta

(Received May 2, 2016; Accepted August 10, 2016)

Keywords: complementary metal-oxide semiconductor (CMOS) image sensor, portable processing system, fluorescence imaging, nitric oxide, cell culture experiment

Fluorescence imaging is a powerful tool for studying the functions of nitric oxide (NO). To improve this method of studying the mechanisms of NO related with behaviors in freely moving animals, we developed a miniature imaging device with a portable processing system. The miniature device was integrated with a complementary metal-oxide semiconductor (CMOS) image sensor, blue light-emitting diodes as an excitation NO probe, and an absorption filter for filtering the excitation light. The portable processing system is lightweight and can be placed on a small animal body. We successfully detected fluorescent images in living cells and captured mouse brain surfaces under implantation conditions using the imaging device. Furthermore, we determined that our device contributes to understanding the in vivo functions of NO in a small animal body.

Corresponding author: Makito Haruta


Cite this article
Anek Wuthayavanich, Makito Haruta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta, Miniature Imaging Device with a Portable Processing System for Fluorescence Detection of Nitric Oxide in Living, Sens. Mater., Vol. 28, No. 12, 2016, p. 1317-1327.



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