pp. 1009-1017
S&M1558 Research Paper https://doi.org/10.18494/SAM.2018.1815 Published: May 18, 2018 Directional Coupler Biosensor with Molecularly Imprinted Polymer [PDF] Ken Uchiyamada, Kyohei Okubo, Kiyoshi Asakawaa, Yuri Kamon, Yukiya Kitayama, Toshifumi Takeuchi, and Hiroaki Suzuki (Received November 24, 2017; Accepted January 4, 2018) Keywords: directional coupler, silicon nitride waveguide, molecularly imprinted polymer (MIP), human serum albumin (HSA)
A microfabricated directional coupler (DC) was used for the label-free, real-time detection of proteins. As an alternative to biomolecules such as antibodies, molecularly imprinted polymer (MIP) was used. With human serum albumin (HSA) as a model analyte, distinct responses were observed. On the other hand, the sensor did not respond to bovine serum albumin (BSA). Also, with a nonimprinted polymer (NIP), no responses were observed for HSA. The MIP could be regenerated, and responses of the same sensor after three cycles of measurement and regeneration gave similar values.
Corresponding author: Hiroaki SuzukiCite this article Ken Uchiyamada, Kyohei Okubo, Kiyoshi Asakawaa, Yuri Kamon, Yukiya Kitayama, Toshifumi Takeuchi, and Hiroaki Suzuki, Directional Coupler Biosensor with Molecularly Imprinted Polymer, Sens. Mater., Vol. 30, No. 5, 2018, p. 1009-1017. |