In this paper, we propose a compact electrical cell-substrate impedance sensing (ECIS) system and a user interface for control and monitoring over the Internet. Since the proposed system is much smaller than existing devices and does not need input/output (I/O) devices, it is easy to install and prevents inadvertent user interaction. The proposed system can increase the efficiency of biological testing devices such as ECIS systems that require long-term experiments at long intervals. The temporal impedance change is measured and recorded on the embedded computer in the proposed system, and the resulting data can be displayed and controlled over the Internet using a web-based graphical user interface (GUI). Bioengineers are currently using the proposed systems for cell culture experiments and are very satisfied with the ease of installation and the ability to observe the experimental situation anytime and anywhere.