In this study, we develop an autonomous process of conducting an assembly task by attaching systematic assembly sequence information to an object's computer-aided design (CAD) model. The information registered in the CAD model is then captured to arrange the robot trajectory, programmable logic controller commands, part three-dimensional printing, and actuator/vision system commands. The vision system can feedback information to modify the CAD model, the operating system, and the position errors in the robot space to achieve the cyber-physical-robotic system (CPRS) closed-loop control. This innovative system can reduce the fixture implementation time, the (robot) manual teaching time, the error variation, and the demand for robot teaching experts in production lines in fast-changing and easy expansion situations. The capability of automatic trajectory generation will increase the precision of the operation to extend the work range from tasks such as loading-unloading, pallet, spray, and welding, which rely on a tolerance of about ±0.5 mm, to assembly, which relies on a tolerance of ±0.1 mm.