pp. 3227-3240
S&M3387 Research Paper of Special Issue https://doi.org/10.18494/SAM4563 Published: September 28, 2023 Miniaturized Neural Observation System for in vivo Brain Imaging in Freely Moving Rats [PDF] Ronnakorn Siwadamrongpong, Yoshinori Sunaga, Kiyotaka Sasagawa, Yasumi Ohta, Hironari Takehara, Makito Haruta,Hiroyuki Tashiro, and Jun Ohta (Received June 28, 2023; Accepted September 11, 2023) Keywords: CMOS image sensor, implantable device, brain surface imaging, in vivo imaging
In this study, we developed a miniaturized observation system for rat brain imaging using an implantable imager. A small data-acquisition device was designed to be mounted on the back of an adult rat, reducing the disturbance to the output of the imager caused by a long cable. With a weight of approximately 6.8 g, the movement of adult rats with an average weight of 200 g was unrestricted. The readout characteristics were evaluated at the light level. The in vivo experiments were performed using mice and freely moving rats. Using the developed data analysis pipeline, blood flow in the vessels was observed.
Corresponding author: Kiyotaka SasagawaThis work is licensed under a Creative Commons Attribution 4.0 International License. Cite this article Ronnakorn Siwadamrongpong, Yoshinori Sunaga, Kiyotaka Sasagawa, Yasumi Ohta, Hironari Takehara, Makito Haruta,Hiroyuki Tashiro, and Jun Ohta, Miniaturized Neural Observation System for in vivo Brain Imaging in Freely Moving Rats, Sens. Mater., Vol. 35, No. 9, 2023, p. 3227-3240. |