pp. 4089-4099
S&M3786 Research Paper of Special Issue https://doi.org/10.18494/SAM4844 Published: September 30, 2024 Visual Determination of Serum Copper (II) by Zinc-containing Mesoporous Silica [PDF] Akari Hashimoto, Kanan Hujinuma, Misato Sakamoto, Yusuke Takahashi, Yukiko Moriiwa, Atsushi Shoji, and Masao Sugawara (Received January 2, 2024; Accepted August 30, 2024) Keywords: colorimetric analysis, zincon, mesoporous silica, complex formation in nanopores
The formation of complexes with the chromophore zincon within the nanopores of aminated mesoporous silica was employed to develop a simple colorimetric method for the detection of copper (II) in human serum. In this method, the sedimentation of the aminated mesoporous silica encapsulating zincon allowed for the detection of a distinct color change, resulting in the detection of copper in the 0–6 µM range. Although zincon forms complexes with both copper (II) and zinc (II) in bulk solution, this complexation within the nanopores enabled the selective detection of copper (II). When this method was applied to the measurement of copper (II) in human serum, the measured values were comparable to those obtained by the conventional method using basocuproindisulfonic acid.
Corresponding author: Atsushi ShojiThis work is licensed under a Creative Commons Attribution 4.0 International License. Cite this article Akari Hashimoto, Kanan Hujinuma, Misato Sakamoto, Yusuke Takahashi, Yukiko Moriiwa, Atsushi Shoji, and Masao Sugawara, Visual Determination of Serum Copper (II) by Zinc-containing Mesoporous Silica, Sens. Mater., Vol. 36, No. 9, 2024, p. 4089-4099. |