pp. 1293-1299
S&M3246 Research Paper of Special Issue https://doi.org/10.18494/SAM4164 Published: April 11, 2023 Engineering Oral Microenvironments Using Microphysiological Systems [PDF] Yuji Nashimoto, Takeshi Hori, Serge Ostrovidov, Sayaka Katagiri, and Hirokazu Kaji (Received October 7, 2022; Accepted November 17, 2022) Keywords: microphysiological system, organ-on-a-chip, oral microenvironment, microfluidic device
A deeper understanding of oral homeostasis and a precise evaluation of the effects of foreign materials are crucial for the oral health and total quality of life. Microphysiological systems (MPSs) or organs-on-chips have emerged over the past decade as attractive tools for emulating the physiological functions of organs in vitro. An MPS can pattern cells and matrices in a tiny microfluidic chip, which realizes in vivo-like cellular interactions and biochemical and physical forces. From this review, we summarize recent developments in MPSs that mimic the oral microenvironment. Oral MPSs can effectively evaluate the toxicity of dental materials in the oral cavity and recapitulate morphogenesis in the oral microenvironment. Oral MPSs are valuable tools for screening dental materials and understanding the development of oral tissues.
Corresponding author: Yuji Nashimoto, Hirokazu KajiThis work is licensed under a Creative Commons Attribution 4.0 International License. Cite this article Yuji Nashimoto, Takeshi Hori, Serge Ostrovidov, Sayaka Katagiri, and Hirokazu Kaji , Engineering Oral Microenvironments Using Microphysiological Systems, Sens. Mater., Vol. 35, No. 4, 2023, p. 1293-1299. |