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Vol. 34, No. 8(3), S&M3042

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Vol. 32, No. 8(2), S&M2292

Print: ISSN 0914-4935
Online: ISSN 2435-0869
Sensors and Materials
is an international peer-reviewed open access journal to provide a forum for researchers working in multidisciplinary fields of sensing technology.
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Sensors and Materials, Volume 36, Number 9(4) (2024)
Copyright(C) MYU K.K.
pp. 4123-4133
S&M3789 Research Paper of Special Issue
https://doi.org/10.18494/SAM5248
Published: September 30, 2024

Development of a Pipette-tip-based Colorimetric Biosensor for On-site Diagnosis of Blood Urea Nitrogen [PDF]

Konoka Nakamura, Hayate Kitazume, Shoji Yamamoto, Hizuru Nakajima, Yukiko Moriiwa, Atsushi Shoji, Akio Yanagida, and Kazuhiro Morioka

(Received July 22, 2024; Accepted September 24, 2024)

Keywords: pipette-tip-based biosensor, urea, smartphone-assisted colorimetric analysis, BUN, on-site diagnosis

A urea quantification method integrated with a pipette-tip-based biosensor and a smartphone was developed for the on-site diagnosis of blood urea nitrogen. When a sample solution containing phenol red is drawn into a pipette tip with urease immobilized on its inner wall, the color of the solution changes due to an enzymatic reaction. The urea concentration can be quantified by photographing the pipette tip with a smartphone and quantifying the color intensity of the solution. In actual urea measurements, the detection limit (3σ) was estimated to be 1.3 mg/dL, indicating that the method has sufficient performance to quantify urea in serum. Furthermore, the method was found to reduce sample consumption and analysis time to 1/10 and 1/3, respectively, compared with conventional methods using microwell plates. This method requires only a micropipette and a smartphone to carry out measurements and does not require bench-top precision equipment or special training. Therefore, the method is expected to develop into a practical analytical platform for biomarker diagnostics that can be used in the field.

Corresponding author: Kazuhiro Morioka


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Cite this article
Konoka Nakamura, Hayate Kitazume, Shoji Yamamoto, Hizuru Nakajima, Yukiko Moriiwa, Atsushi Shoji, Akio Yanagida, and Kazuhiro Morioka, Development of a Pipette-tip-based Colorimetric Biosensor for On-site Diagnosis of Blood Urea Nitrogen, Sens. Mater., Vol. 36, No. 9, 2024, p. 4123-4133.



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